313 episodes

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

Paul Saladino MD podcast Paul Saladino, MD

    • Health & Fitness
    • 4.8 • 2.4K Ratings

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

    248. Why I Built a Food Company with Anthony Gustin

    248. Why I Built a Food Company with Anthony Gustin

    While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality.



    Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt

    *Produced by Mountain Valley Media

    00:00:00 Podcast begins
    00:03:00 The devaluation of food preparation in modern society
    00:09:00 how supply chain issues contribute to poor food quality
    00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet
    00:28:47 Ads
    00:45:21 Why most “grass-finished” beef isn’t what you think it is
    01:05:09 Lineage Ad
    01:13:21 Paul’s beef with seafood
    01:21:20 Testing for PFAs
    01:25:17 What to expect from Lineage Provisions
    01:28:45 Answering FAQs about Lineage Provision’s meat sticks

    Buy Lineage Beef Sticks: https://lineageprovisions.com/products/classic-meat-sticks

    • 1 hr 41 min
    247. Gary Brecka: Tap Water is Lowering Your IQ!

    247. Gary Brecka: Tap Water is Lowering Your IQ!

    Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.



    *Produced by ⁠Mountain Valley Media



    00:00:00 Podcast begins

    00:01:23 What is fluoride and is it harmful?

    00:07:30 How to filter your water

    00:09:00 Western medicine & longevity

    00:27:00 Food sourcing and big food

    00:30:50 Cyanocobalamin

    00:34:55 Folic acid

    00:42:00 Gathering objective & subjective data

    00:49:00 The importance of gene testing & methylation

    • 1 hr 7 min
    246. Some things I'm experimenting with lately...

    246. Some things I'm experimenting with lately...

    On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.



    *Produced by ⁠Mountain Valley Media

    00:00:00 The importance of heart & riboflavin
    00:08:30 Pauls new company: Lineage
    00:10:50 Thoughts on creatine
    00:19:10 Paul’s experience with white rice & potatoes
    00:24:45 Paul experimenting with supplements for methylation

    Check out Lineage Meat Sticks: https://lineageprovisions.com/password

    References:
    Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

    • 30 min
    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.



    *Produced by ⁠Mountain Valley Media

    00:00:00 Podcast begins
    00:04:00 Mike’s background
    00:05:15 Diving into fructose
    00:13:00 Thoughts on honey and other carb sources
    00:27:30 Robert Lustig rebuttal: is fructose addictive?
    00:37:40 Fructose & fiber
    00:47:00 How fructose affects the mitochondria
    00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia
    00:56:17 Is insulin the bad guy?
    01:12:20 How insulin relates to diabetes, obesity, and insulin resistance
    01:23:30 Balancing protein, fat and carbohydrates
    01:30:00 Is fructose making us fat?
    01:46:00 Final thoughts


    Connect with Mike:
    Mikefave.com
    https://m.youtube.com/@MikeFaveSimplified


    References:
    Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

    A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

    A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/

    A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

    The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

    Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/

    The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

    The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

    Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/

    Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/

    Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/

    Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/

    Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/

    Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/

    Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/

    Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

    Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/

    Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

    • 1 hr 54 min
    244. Longevity Alert: The Dark Side of Olive Oil Revealed with Brad Marshall

    244. Longevity Alert: The Dark Side of Olive Oil Revealed with Brad Marshall

    On this week's podcast, Brad Marshall, evolutionary biologist, talks with Paul about how signaling to our body that winter is coming is not advantageous for humans and why humans may want to stop consuming olive oil. They do a deep dive into the human metabolism, what European diets are truly like, and touch on other kinds of oils & fats as well.



    *Produced by ⁠Mountain Valley Media



    00:00:00 Podcast begins

    00:02:50 Brad’s weight loss journey

    00:10:50 The human metabolism

    00:15:10 How olive oil makes us fat

    00:34:24 Deep dive into European diets

    00:48:50 PREDIMED trial comparing different types of olive oil

    00:51:05 De novo lipogenesis (DNL)

    00:53:50 What happens when humans eat canola oil

    00:59:20 A story about the Inuit & long-term ketosis

    01:07:20 Takeaways about olive oil



    Connect with Brad:

    https://www.youtube.com/@fireinabottle3410



    References:

    Diabetes prevalence, 2021: https://ourworldindata.org/grapher/diabetes-prevalence



    Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018: https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0264778.g004



    OBESITY AMONG CHILDREN IN EUROPE: https://landgeist.com/2023/02/18/obesity-among-children-in-europe/



    Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030: https://pubmed.ncbi.nlm.nih.gov/29886156/



    Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study: https://www.lipidjournal.com/article/S1933-2874(18)30362-3/fulltext



    Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315420/

    • 1 hr 17 min
    243. Responding to Layne Norton on SEED OILS

    243. Responding to Layne Norton on SEED OILS

    This episode is my response to Layne’s video about seed oils. Due to the pervasive mainstream support for seed oils, I believe it’s extremely important to shed some light on the hidden truth behind these oils. There is a lot of conflicting evidence on seed oils out there. Looking at the totality of the evidence can be very misleading, so we must look at the details. By thoroughly breaking down each trial from Layne’s video, we can see massive flaws in the methods and designs of each study. Trans fat consumption by the control group and multifactorial interventions in the experimental group were the primary confounding variables.

    In this video, Paul references several studies suggesting different ways in which seed oils are harmful to humans. He always appreciate differing views and these discussions because it’s how we all learn. He has hope that a respectful debate will happen in the future so that we can dive deeper into this important subject. He strongly believe that seed oils are evolutionarily inconsistent, these are not the fats that humans have evolved on. In fact, we have evolved by consuming ample amounts of animal fats, rich in saturated fats. Saturated fats have been shown to lower markers of heart disease and they are an amazing source of essential vitamins like A, D3, K2, E.

    It's always meat / organs / fruit / honey / raw dairy. This is an ANIMAL-BASED diet, and I believe this is the most optimal diet for humans on the planet.

    Check out my ANIMAL-BASED CALCULATOR here: https://www.paulsaladinomd.co/ab-guide



    Listen on YouTube: https://www.youtube.com/watch?v=8QhWNBXamCM&t=1s



    Sign-up for Animal Based 30: https://heartandsoil.co/animalbased30/

    00:00 Intro
    02:57 Randomized controlled trials in humans
    03:47 Flaws found in the studies
    04:42 Reviewing each trial
    16:10 What’s the takeaway
    19:45 Studies against seed oils
    26:30 Toxic compounds in seed oils
    27:32 Responding to Layne’s claims
    36:10 Closing thoughts


    References:

    Meta-analysis of RCT by C. Ramsden - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Meta-analysis of RCT by S. Hamley - https://www.ncbi.nlm.nih.gov/pmc/arti...

    PUFA increases lipid peroxidation - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Linoleic acid metabolites in metabolic syndromes - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Lower saturated fat increases oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/14739...

    More linoleic acid increases oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/9488997/

    OXLAMs in atherosclerosis - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Oxidized LDL and metabolic syndrome - https://pubmed.ncbi.nlm.nih.gov/19802...

    De novo lipogenis through oxidized LDL and linoleic acid - https://pubmed.ncbi.nlm.nih.gov/27020...

    Lower linoleic acid reduces oxidized metabolites - https://www.ncbi.nlm.nih.gov/pmc/arti...

    Soybean oil increase Lp-PLA2 and oxidized LDL - https://pubmed.ncbi.nlm.nih.gov/28503...

    Saturated fat lowers Lp(a) - https://pubmed.ncbi.nlm.nih.gov/9327759/

    Benzene in seed oils - https://pubmed.ncbi.nlm.nih.gov/11064...

    Heavy metals in seed oils - https://www.mdpi.com/2076-3417/13/5/3020

    Phthalates in seed oils - https://pubmed.ncbi.nlm.nih.gov/37726...

    • 36 min

Customer Reviews

4.8 out of 5
2.4K Ratings

2.4K Ratings

idahowapiti ,

Awesome, But……

Great podcast but maybe a little less pimping of the supplements

Fabdadwife ,

Too complicated for even a health fanatic

I came to hear the debate about seed oils in response to Layne Norton. 20 minutes in and I still have no idea what your stance is- if you are for or against. And siting research from the 70s!?? I had to tune out. I don’t even know what you were trying to say, and I’m a college graduate with nutrition courses under my belt.

ALadywithFrizzyHair ,

A much-belated review

I have waited 5 years to write this review.

This is, in part, because I was curious and a bit conflicted about Paul for a long time. I was a carnivore back in 2019 and Paul was already a rising authority figure in the animal-based space. In a sea of people trying to out-quote one another on the latest study, I wondered: could I trust his information? Does he stick to the science or just quote studies that back his beliefs while ignoring studies that showed counter evidence? Is he self-serving and driven by his ego? Or does he really care about his community and listeners?

5 years later, I can’t say I have definitive answers to these questions because I have never met Paul. What I have learned about Paul is that he is curious, a searcher who seeks wisdom through knowledge and experience, and is willing to admit when he’s wrong or changes his mind. He’s always trying to expand his knowledge and experiment with ideas that go against the grain. He tries to interpret studies with the information we have and bring people on to have counterpoints (even if sometimes he gets a little one-track-minded with his debating style). Does he sometimes get overenthusiastic with his ads for his expensive supplements? Sure, but I guess the man’s gotta make a living when he packs his things and hoofs it down to Costa Rica with only his surfboard and a disdain for kale.

I also used to interpret Paul as aggressive, pushy, or as a bully, but I’ve learned that only happens when he gets really excited about something. It’s a different energy, sometimes a little bit TOO much energy, but Paul has shown himself to be more open than I initially thought. He’s changed my mind about him and I thank him for sharing all these years. For all that, he gets 4 stars from me.

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